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This strategy is the basis for many anticancer therapeutics, including chemotherapeutics, radiotherapies, and most small-molecule inhibitor-based therapies, which impair tumor metabolism and induce excessive ROS accumulation, inducing cell toxicity and death

388 Knockout of 2,6-sialyltransferase suppresses the polarization of CD4 + T cells to Th17 cells while promoting their polarization to Treg cells, inhibiting the secretion of IL-17a, and alleviating UC symptoms

The degradation function of lysosomes has been adequately studied for decades, but studies on the roles of lysosomes as cellular sensors and signal hubs are in an initial state